The Murray Region covers the NSW portion of the Murray catchment covering an area of 35,170 square kilometres from the Great Dividing Range in the east, to the junction of the Murray and Murrumbidgee rivers west of Swan Hill.

The catchment region is bounded by the Murray River to the south, the Murrumbidgee River Catchment divide to the north, the Australian Alps to the east and the confluence of the Murrumbidgee and Murray rivers to the west.